One of the SSBB Doctoral Candidates published a review about the mechanisms, effects, and applications of HMOs and polyphenols in allergies. In this review, we outline the basic biology of HMO and polyphenols and deeply characterize their effects on the development of allergic disorders on the basis of available literature reporting data from in vitro, animal, and human studies. Further, we review the abundance of HMO and polyphenols, commonly present in mother’s milk, and their mutual interactions in the context of the mechanisms underlying predisposition to, or protection against, the development of allergies. Finally, we discuss the potential of HMO and polyphenols in allergy prevention and therapy.
Human milk oligosaccharides and polyphenols: Mechanisms, effects, and applications in allergies. C.C.M. den Elzen, A. Carvalho, S. Bazan-Socha, P.V. Jeurink, M. Wygrecka, M. Kool, J. Garssen, D.P. Potaczek, H. Garn, B. van Esch. J. Allergy Clin. Immunol. 2026 Jan;157(1):18-37. doi: 10.1016/j.jaci.2025.09.029. Full publication.
