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Implant material governs SET-M33’s antimicrobial effectiveness

Four SSBB doctoral candidates from three different partners worked together and published a paper about the efficacy of the SET-M33 antimicrobial peptide in combination with different implant materials that enter the cardiac implantable electronic devices surgical pocket. The tests presented in the paper include the in vitro evaluation of (i) the ability of molecules to permeate porous materials and diffuse in aqueous solution and (ii) to efficiently eradicate bacterial contamination. Altogether, the work identified viable biomaterials/antimicrobial combinations and indicates the optimal strategy for their deployment in surgical settings. Maranesi A., Mohammadi S., Castanon I., Gama-Franceschi F., Falciani C., Pini A., Mezzanotte L., Unger W. and Ferrari A. Sci Rep. 2025 May 10;15:16353. DOI: 10.1038/s41598-025-99808-w. Full publication.

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