The SSBB project have published the results from a collaborative study of different consortium partners. In this study, the potential of biosynthesized cellulose membranes as drug carriers to present antimicrobial peptides at the cardiac implantable electronic devices interface has been investigated. Specifically, the ability to target S. aureus biofilm formation was assessed. The results reported demonstrate the feasibility of exploiting biosynthesized cellulose as antimicrobial peptide carrier for inhibiting biofilm formation in conditions relevant to deployment of cardiac implantable electronic devices. While further in vivo evaluation is needed, this approach may offer a promising path to address antimicrobial resistance in the management of post-operative infections associated with cardiac implantable electronic device implants.
SET-M33 loaded biosynthesized cellulose as effective protection against S. aureus biofilm formation. Mohammadi S., Maranesi A., de Bruin A.C.J.M., Castanon I., Gierlich P., Falciani C., Pini A., van Beusekom H.M.M., Ferrari A. and Unger W.W.J. Biofilm. 2026 Feb 2:11:100351. doi: 10.1016/j.bioflm.2026.100351. eCollection 2026 Jun. Full publication.
